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KMID : 0387820120190010049
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Clinical Pediatric Hematology-Oncology
2012 Volume.19 No. 1 p.49 ~ p.52
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A Case of Epstein-Barr Virus Associated Hemophagocytic Lymphohistiocytosis after Scrub Typhus Infection
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Hong Ji-Hye
Cho Hyun-Jun
Kim Hwang-Min
Namgoon Mee-Kyung
Kwon Oh-Gun
Chun Jin-Kyoung
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Abstract
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7-year-old boy with pancytopenia, cervical lymphadenopathy, interstitial pneumonia, and hepatosplenomegaly was diagnosed with Epstein-Barr Virus (EBV)-associated hemophagocytic lymphohistiocytosis. His clinical course was characterized by hepatorenal syndrome and myocarditis. Based on his serological markers for EBV and an immunochromatography test for scrub typhus, this case was inferred as an EBV infection that was reactivated during tsutsugamushi infection. We treated this patient with the HLH-2004 protocol and administered clarithromycin. Normal ferritin level was achieved within 8 weeks after starting chemotherapy and antibiotics.
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KEYWORD
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ocytic lymphohistiocytosis, Scrub typhus, Epstein-Barr virus
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